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Single-view neural illumination estimation and editing for dynamic light field display - Light: Science & Applications
5+ hour, 29+ min ago (1688+ words) From a first-principles optics perspective, any visual scene is comprehensively described by its light field, a fundamental concept that characterizes the flow of light in free space. In its complete form, the light field is represented by the 5D Plenoptic Function,…...
Genome modelling and design across all domains of life with Evo 2
17+ hour, 55+ min ago (1437+ words) Emphasizing generalist capabilities over task-specific optimization, Evo 2 represents an important milestone in biological sequence modelling, laying a broad foundation for prediction and design tasks that are relevant to all modalities of the central dogma, that span molecular to genome scale…...
Merlin: a computed tomography vision–language foundation model and dataset
18+ hour, 20+ min ago (1506+ words) Sch'ckel, L. et al. Developments in X-ray contrast media and the potential impact on computed tomography. Invest. Radiol. 55, 592597 (2020). Kanal, K. M. et al. U.S. diagnostic reference levels and achievable doses for 10 adult CT examinations. Radiology 284, 120133 (2017). Rimmer, A. Radiologist shortage leaves patient care at risk, warns…...
Reinforcement learning-based design of sequential drug treatment targeting the evolving tumour landscape with SequenTx - Nature Machine Intelligence
21+ hour, 43+ min ago (1334+ words) Parreno, V. et al. Transient loss of polycomb components induces an epigenetic cancer fate. Nature 629, 688696 (2024). Brown, R., Curry, E., Magnani, L., Wilhelm-Benartzi, C. S. & Borley, J. Poised epigenetic states and acquired drug resistance in cancer. Nat. Rev. Cancer 14, 747753 (2014). Bunne, C. et al. How to build the virtual cell…...
Hunt for reactive metabolites uncovers unusual chemistry in a human pathogen
1+ day, 5+ hour ago (163+ words) Expert opinion" and the figure are published under a CC BY 4.0 licence. Wilson, M. R. et al. Science 363, eaar7785 (2019). Nawrat, C. C. & Moody, C. J. Nat. Prod. Rep. 28, 14261444 (2011). Harris, L. A. & Mitchell, D. A. Methods Enzymol. 665, 177208 (2022). Huang, J. et al. Nature 617, 403408 (2023). Van Cura, D. et al. Angew. Chem. Int. Edn 62, e202304646 (2023). DICER cleavage fidelity…...
Bridging structure and function: artificial intelligence-based modelling of kidney proteins - Nature Reviews Nephrology
1+ day, 5+ hour ago (1737+ words) Structural insights from AI models have clarified mechanisms of kidney disease by mapping mutations in key proteins; these analyses have revealed how sequence variants disrupt folding, domain organization and conformational dynamics in disorders such as distal renal tubular acidosis, Gitelman…...
3D Magic Mirror: clothing reconstruction from a single image via a causal perspective - npj Artificial Intelligence
1+ day, 14+ hour ago (1747+ words) Next, we discuss existing works on 3D reconstruction from a single image and explain the causal learning followed by a brief illustration of expectation maximization. The illumination encoder is to regress the illumination direction and strength, which can be simply formulated…...
Low-input deep learning platform for citrullinated peptide identification, autoantigen discovery and rheumatoid arthritis treatment stratification - Nature Biomedical Engineering
1+ day, 21+ hour ago (1667+ words) These authors contributed equally: Meng Hu, Chenxi Zhu, Rui Sun, Zhiqiang Xu, Yanqiu Gong, Yi Liu. Department of Rheumatology and Immunology and Department of Laboratory Medicine, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital,…...
Releasing open-weight AI in steps would alleviate risks
1+ day, 21+ hour ago (171+ words) Nature 651, 274 (2026) UN creates new scientific AI advisory panel: what will it do? News 26 FEB 26 Laser-written glass tablets can preserve data for millennia News & Views 18 FEB 26 This AI can improve your peer review " and make it more polite News 23 FEB 26 South…...
TANGO: direct optimization of constrained synthesizability for generative molecular design - Nature Computational Science
1+ day, 22+ hour ago (1395+ words) A preprint version of the article is available at arXiv. Gao, W. & Coley, C. W. The synthesizability of molecules proposed by generative models. J. Chem. Inf. Model. 60, 57145723 (2020). Stanley, M. & Segler, M. Fake it until you make it? Generative de novo design and virtual screening of synthesizable…...