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Artificial allosteric protein switches with machine-learning-designed receptors - Nature Biotechnology
2+ day, 1+ hour ago (1730+ words) We also generated focused libraries of "-lactamase chimeras with circular permutated minibinders of the Vir B8-like and MDM2 proteins15 (Fig. 2g and Supplementary Fig. 4e, f). In both cases, we were able to obtain chimeras with ligand-controlled enzymatic activity (Fig. 1g and Supplementary Fig. 4g). These results…...
About the Collection | Generative Models in Engineering Biology
2+ day, 12+ hour ago (112+ words) This Collection supports and amplifies research related to SDG 9and SDG 12. In this cross-journal Collection between Nature Communications, Communications Biology, Communications Chemistry, npj Systems Biology and Applications, and npj Biosensing, we aim to bring together the latest and most compelling demonstration…...
Dozens of AI disease-prediction models were trained on dubious data
2+ day, 6+ hour ago (725+ words) Dubious data sets are being used to train artificial-intelligence models that are designed to predict people's risk of stroke and diabetes, researchers report in a preprint1 on med Rxiv. Some of the models seem to have been used in clinical settings…...
Phenotypic prediction of missense variants via deep contrastive learning - Nature Biomedical Engineering
2+ day, 12+ hour ago (1731+ words) Lappalainen, T. & Mac Arthur, D. G. From variant to function in human disease genetics. Science 373, 14641468 (2021). Chong, J. X. et al. The genetic basis of Mendelian phenotypes: discoveries, challenges, and opportunities. Am. J. Hum. Genet. 97, 199215 (2015). Venugopal, A. et al. Monogenic diseases in India. Mutat. Res. Rev. Mutat. Res....
Fast and accurate multiple-protein-sequence alignment at scale with FAMSA2 - Nature Biotechnology
3+ day, 51+ min ago (837+ words) Satam, H. et al. Next-generation sequencing technology: current trends and advancements. Biology 12, 997 (2023). Lewin, H. A. et al. Earth Bio Genome Project: sequencing life for the future of life. Proc. Natl Acad. Sci. USA 115, 43254333 (2018). Richardson, L. et al. MGnify: the microbiome sequence data analysis resource…...
Machine learning for materials discovery and optimization
9+ mon, 2+ week ago (87+ words) This Collection supports and amplifies research related to SDG 9 -Industry, Innovation & Infrastructure. Topics of interest include, but are not limited to, the following approaches: The Collection will publish original research papers, Reviews, and Perspectives (full details on content types can…...
Communicating science effectively in the age of AI
1+ mon, 4+ day ago (517+ words) Throughout history, technology " from the printing press to the internet " has led to fundamental societal shifts, transforming how we live, and what we are capable of. Now we face another turning point, as AI begins to shape our decisions, opportunities…...
Fluid-Structure Interaction Analysis and Applications
9+ mon, 1+ day ago (417+ words) Fluid'structure interaction (FSI) analysis represents a critical interdisciplinary field that bridges computational fluid dynamics and structural mechanics. It enables the detailed simulation of the. .. Fluid-Structure Interaction Analysis and Applications Fluid'structure interaction (FSI) analysis represents a critical interdisciplinary field that bridges…...
Systematic Review and Machine Learning in Evidence-Based Medicine
9+ mon, 1+ day ago (122+ words) Systematic Review: A rigorous method for collating and synthesising research evidence to answer a specific question, typically involving predefined selection criteria and reproducible methods. Machine Learning: A branch of artificial intelligence where algorithms learn from data to make predictions or…...
Bayesian Methods in Structural Equation Modeling
9+ mon, 1+ day ago (89+ words) Latent Variables: Unobserved constructs inferred from observed data that explain underlying patterns and correlations within the data set. Prior Distribution: The probability distribution representing initial beliefs about a parameter before data is taken into account. Posterior Distribution: The updated probability…...