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Interpretation, extrapolation and perturbation of single cells
6+ hour, 30+ min ago (1684+ words) Nature Reviews Genetics (2026)Cite this article Regev, A. et al. The human cell atlas. eLife 6, e27041 (2017). Rood, J. E. et al. The Human Cell Atlas from a cell census to a unified foundation model. Nature 637, 10651071 (2025). Argelaguet, R. et al. MOFA+: a statistical framework for comprehensive…...
Reinforcement learning-driven feature selection enhanced by an evolutionary approach tuning for criminal suspect identification
1+ day, 6+ hour ago (1312+ words) This loss is computed directly from physically measured intensities at the sensor plane. Since \(f(\cdot )\) represents the actual light propagation and detection process within our experimental setup, the optimization inherently captures all system nonidealities, imperfections, aberrations, misalignments and noise…...
Pertpy: an end-to-end framework for perturbation analysis
1+ day, 14+ hour ago (1617+ words) Nature Methods (2025)Cite this article a, UMAP representation of the preprocessed dataset, colored by perturbation status, cell cycle phase and GEM group (that is, batch of cells processed in the same lane on a 10x Genomics chip). b, Perturbation space highlighting…...
MATTERIX: toward a digital twin for robotics-assisted chemistry laboratory automation
1+ day, 20+ hour ago (1377+ words) Receive 12 digital issues and online access to articles only $9.92 per issue All data required to evaluate the presented conclusions are available within the Article and its Supplementary Information. All supporting data were generated using the MATTERIX code. Source data are…...
doi:10.1038/d41586-025-04007-2
2+ day, 2+ hour ago (239+ words) This is a summary of: Clements, H. S. et al. A place-based assessment of biodiversity intactness in sub-Saharan Africa. Nature 649, 113121 (2026). "Expert opinion" and the figure are published under a CC BY 4.0 licence. Stephenson, P. J. et al. Biol. Conserv. 213, 335340 (2017). Clements, H. S. et al. Sci. Data…...
Explainable artificial intelligence with negative sample optimization for archaeological site prediction in Surkhandarya Uzbekistan
2+ day, 2+ hour ago (1606+ words) The map illustrates the physiographic background of the Surkhandarya River Basin, flanked by the Zarafshan and Gissar Mountains. Elevation gradients are shown from white (high) to blue (low). The Amu Darya River defines the southern boundary. Red dots represent 189 ancient…...
Digital twins for self-driving chemistry laboratories
2+ day, 2+ hour ago (183+ words) Digital twins of self-driving chemistry laboratories may help reduce reliance on costly real-world experimentation and enable the testing of hypothetical automated workflows in silico. Receive 12 digital issues and online access to articles only $9.92 per issue Tao, F., Zhang, H. & Zhang, C. Nat. Comput....
CICHMKG: a large-scale and comprehensive Chinese intangible cultural heritage multimodal knowledge graph
2+ day, 2+ hour ago (1609+ words) This schematic outlines the five key stages of the traditional craft, from raw material preparation to the finished product, and highlights the core tools utilized in each step. (ii) Methodological level: We proposed the NSCEF-ICHKG framework and constructed an XPKG instance…...
The missing data for intelligent scientific instruments
2+ day, 2+ hour ago (152+ words) Nature Methods (2025)Cite this article Jumper, J. et al. Nature 596, 583589 (2021). Boiko, D. A., MacKnight, R., Kline, B. & Gomes, G. Nature 624, 570578 (2023). Szymanski, N. J. et al. Nature 624, 8691 (2023). Eisenstein, M. Nat. Methods 17, 10751079 (2020). Carpenter, A. E., Cimini, B. A. & Eliceiri, K. W. Nat. Methods 20, 962964 (2023). Manning, C., Raghavan, P. & Schuetze, H. Introduction to Information Retrieval (Cambridge Univ. Press, 2009). Zulueta-Coarasa, T. et al. Nat....
Assessing the potential of deep learning for protein–ligand docking
2+ day, 2+ hour ago (1406+ words) A preprint version of the article is available at arXiv. Our benchmark results also highlight the importance of including challenging (out-of-distribution) datasets when evaluating future DL methods and measuring their ability to recapitulate amino acid-specific PLIFs with an appropriate new…...